VU 0469381

CAS No. 1062368-49-3

VU 0469381( 1LWY | VU0469381 | ML347 | ML 347 )

Catalog No. M10277 CAS No. 1062368-49-3

A potent, sellective BMP receptor ALK2 antaognist with Ki of 32 nM, with no affinity for ALK3/4/5/6.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 30 In Stock
5MG 47 In Stock
10MG 69 In Stock
25MG 143 In Stock
50MG 259 In Stock
100MG 441 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    VU 0469381
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, sellective BMP receptor ALK2 antaognist with Ki of 32 nM, with no affinity for ALK3/4/5/6.
  • Description
    A potent, sellective BMP receptor ALK2 antaognist with Ki of 32 nM, with no affinity for ALK3/4/5/6.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    1LWY | VU0469381 | ML347 | ML 347
  • Pathway
    TGF-beta/Smad
  • Target
    TGFBR
  • Recptor
    ALK1|ALK2|ALK3|ALK6
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1062368-49-3
  • Formula Weight
    352.397
  • Molecular Formula
    C22H16N4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 7.1 mg/mL (20 mM) ( < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    COC1=CC=C(C(C=N2)=CN3C2=C(C4=CC=CC5=C4C=CC=N5)C=N3)C=C1
  • Chemical Name
    5-(6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Engers DW, et al. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. 2. Engers DW, et al. Probe Reports from the NIH Molecular Libraries Program. 3. Tsugawa D, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):549-58.
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